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Assay Detail

CHEMBL699561

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
In vitro inhibition of Inosine-5'-monophosphate dehydrogenase 2.
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Inosine-5'-monophosphate dehydrogenase 2 (CHEMBL2002)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Novel guanidine-based inhibitors of inosine monophosphate dehydrogenase.
Iwanowicz EJ, Watterson SH, Liu C, Gu HH, Mitt T, Leftheris K, Barrish JC, Fleener CA, Rouleau K, Sherbina NZ, Hollenbaugh DL.
Bioorg Med Chem Lett (2002) 12 : 2931 -2934
PubMed 12270177 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 21 6.58 7.82

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL866 MYCOPHENOLIC ACID 4.0 1 7.82
CHEMBL101984 1 7.80
CHEMBL65013 1 7.72
CHEMBL101941 1 6.89
CHEMBL101270 1 6.75
CHEMBL98740 1 6.62
CHEMBL60730 1 6.60
CHEMBL99625 1 6.55
CHEMBL101822 1 6.50
CHEMBL98393 1 6.48
CHEMBL98322 1 6.47
CHEMBL101463 1 6.47
CHEMBL99278 1 6.42
CHEMBL98904 1 6.18
CHEMBL317497 1 6.13
CHEMBL329714 1 6.10
CHEMBL98500 1 5.96
CHEMBL98700 1 5.82
CHEMBL316946 1 5.66
CHEMBL98225 1 -
CHEMBL318413 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL866 MYCOPHENOLIC ACID IC50 = 15.0 nM 7.82
CHEMBL101984 IC50 = 16.0 nM 7.80
CHEMBL65013 IC50 = 19.0 nM 7.72
CHEMBL101941 IC50 = 130.0 nM 6.89
CHEMBL101270 IC50 = 180.0 nM 6.75
CHEMBL98740 IC50 = 240.0 nM 6.62
CHEMBL60730 IC50 = 250.0 nM 6.60
CHEMBL99625 IC50 = 280.0 nM 6.55
CHEMBL101822 IC50 = 320.0 nM 6.50
CHEMBL98393 IC50 = 330.0 nM 6.48
CHEMBL98322 IC50 = 340.0 nM 6.47
CHEMBL101463 IC50 = 340.0 nM 6.47
CHEMBL99278 IC50 = 380.0 nM 6.42
CHEMBL98904 IC50 = 660.0 nM 6.18
CHEMBL317497 IC50 = 740.0 nM 6.13
CHEMBL329714 IC50 = 800.0 nM 6.10
CHEMBL98500 IC50 = 1100.0 nM 5.96
CHEMBL98700 IC50 = 1500.0 nM 5.82
CHEMBL316946 IC50 = 2200.0 nM 5.66
CHEMBL98225 IC50 > 1000.0 nM -
CHEMBL318413 IC50 > 3000.0 nM -