Assay Detail
Binding
CHEMBL699574
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Inhibitory activity of compound against perine-specific inosine-adenosine-guanosine nucleoside hydrolase (IAG-NH) from Trypanosoma brucei
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Trypanosoma brucei |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
8-Aza-immucillins as transition-state analogue inhibitors of purine nucleoside phosphorylase and nucleoside hydrolases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 6.58 | 9.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL38245 | — | — | 1 | 9.05 |
| CHEMBL289941 | — | — | 1 | 7.64 |
| CHEMBL218291 | FORODESINE | 4.0 | 1 | 7.62 |
| CHEMBL41949 | — | — | 1 | 5.43 |
| CHEMBL2311112 | — | — | 1 | 4.86 |
| CHEMBL289848 | — | — | 1 | 4.85 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL38245 | — | Ki | = | 0.9 | nM | 9.05 |
| CHEMBL289941 | — | Ki | = | 23.0 | nM | 7.64 |
| CHEMBL218291 | FORODESINE | Ki | = | 24.0 | nM | 7.62 |
| CHEMBL41949 | — | Ki | = | 3700.0 | nM | 5.43 |
| CHEMBL2311112 | — | Ki | = | 13900.0 | nM | 4.86 |
| CHEMBL289848 | — | Ki | = | 14000.0 | nM | 4.85 |