Assay Detail
Functional
CHEMBL699616
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Inhibition against GRO-alpha driven human neutrophil chemotaxis
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
Interleukin-8 receptors, CXCR1/CXCR2 (CHEMBL2096909) ↗| Type | PROTEIN FAMILY |
| Organism | Homo sapiens |
Publication
Nicotinanilides as inhibitors of neutrophil chemotaxis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 23 | 6.53 | 7.38 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL431511 | — | — | 1 | 7.38 |
| CHEMBL36535 | — | — | 1 | 7.37 |
| CHEMBL36934 | — | — | 1 | 7.34 |
| CHEMBL39464 | — | — | 1 | 7.30 |
| CHEMBL432475 | — | — | 1 | 7.08 |
| CHEMBL291140 | — | — | 1 | 7.03 |
| CHEMBL36643 | — | — | 1 | 6.96 |
| CHEMBL39710 | — | — | 1 | 6.80 |
| CHEMBL36842 | — | — | 1 | 6.70 |
| CHEMBL289656 | — | — | 1 | 6.66 |
| CHEMBL288527 | — | — | 1 | 6.66 |
| CHEMBL288876 | — | — | 1 | 6.44 |
| CHEMBL40080 | — | — | 1 | 6.39 |
| CHEMBL40955 | — | — | 1 | 6.17 |
| CHEMBL289789 | — | — | 1 | 6.12 |
| CHEMBL39937 | — | — | 1 | 6.00 |
| CHEMBL40558 | — | — | 1 | 5.57 |
| CHEMBL39988 | — | — | 1 | 5.29 |
| CHEMBL40114 | — | — | 1 | 4.90 |
| CHEMBL36797 | — | — | 1 | - |
| CHEMBL39835 | — | — | 1 | - |
| CHEMBL35938 | — | — | 1 | - |
| CHEMBL288457 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL431511 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL36535 | — | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL36934 | — | IC50 | = | 46.0 | nM | 7.34 |
| CHEMBL39464 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL432475 | — | IC50 | = | 83.0 | nM | 7.08 |
| CHEMBL291140 | — | IC50 | = | 94.0 | nM | 7.03 |
| CHEMBL36643 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL39710 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL36842 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL289656 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL288527 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL288876 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL40080 | — | IC50 | = | 410.0 | nM | 6.39 |
| CHEMBL40955 | — | IC50 | = | 680.0 | nM | 6.17 |
| CHEMBL289789 | — | IC50 | = | 760.0 | nM | 6.12 |
| CHEMBL39937 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL40558 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL39988 | — | IC50 | = | 5100.0 | nM | 5.29 |
| CHEMBL40114 | — | IC50 | = | 12500.0 | nM | 4.90 |
| CHEMBL36797 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL39835 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL35938 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL288457 | — | IC50 | > | 20000.0 | nM | - |