Assay Detail
Binding
CHEMBL699630
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Concentration required for 50% inhibition of [3H]Glu binding to AMPA receptor in rat cortical slice preparation in the presence of 2.5 mM CaCl2
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
Glutamate receptor ionotropic, AMPA (CHEMBL2093871) ↗| Type | PROTEIN COMPLEX GROUP |
| Organism | Rattus norvegicus |
Publication
Excitatory amino acid receptor ligands. Synthesis and biological activity of 3-isoxazolol amino acids structurally related to homoibotenic acid.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 7.01 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL9822 | — | — | 1 | 7.70 |
| CHEMBL325291 | — | — | 1 | 6.85 |
| CHEMBL10339 | — | — | 1 | 6.75 |
| CHEMBL268762 | — | — | 1 | 6.75 |
| CHEMBL13378 | (R,S)-AMPA | — | 1 | - |
| CHEMBL113180 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL9822 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL325291 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL10339 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL268762 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL13378 | (R,S)-AMPA | IC50 | > | 100000.0 | nM | - |
| CHEMBL113180 | — | IC50 | > | 100000.0 | nM | - |