Assay Detail
Functional
CHEMBL699700
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Compound was evaluated for its effective dose to inhibit the calcium release as a measure of affinity for Inositol 1,4,5-trisphosphate receptor
3
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
Inositol 1,4,5-trisphosphate receptor (CHEMBL2111451) ↗| Type | PROTEIN FAMILY |
| Organism | Homo sapiens |
Publication
Total synthesis of L-2,2-difluoro-2-deoxy-MYO-inositol 1,4,5-trisphosphate, a potent inhibitor of the enzymes of d-MYO-inositol 1,4,5-trisphosphate metabolism
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 5.85 | 6.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1161456 | — | — | 1 | 6.89 |
| CHEMBL1161466 | — | — | 2 | 6.39 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1161456 | — | EC50 | = | 130.0 | nM | 6.89 |
| CHEMBL1161466 | — | EC50 | = | 410.0 | nM | 6.39 |
| CHEMBL1161466 | — | EC50 | = | 53000.0 | nM | 4.28 |