Assay Detail
Binding
CHEMBL699725
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity against Ionotropic glutamate receptor using [3H]- CGS-19755 displacement from rat forebrain preparations
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Forebrain |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Glutamate receptor ionotropic, kainate 3 (CHEMBL3744) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
(2S,4S)-amino-4-(2,2-diphenylethyl)pentanedioic acid selective group 2 metabotropic glutamate receptor antagonist.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.08 | 5.27 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL351653 | — | — | 1 | 5.27 |
| CHEMBL350704 | — | — | 1 | 4.88 |
| CHEMBL39338 | — | — | 1 | - |
| CHEMBL40123 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL351653 | — | IC50 | = | 5400.0 | nM | 5.27 |
| CHEMBL350704 | — | IC50 | = | 13200.0 | nM | 4.88 |
| CHEMBL39338 | — | IC50 | = | 147000.0 | nM | - |
| CHEMBL40123 | — | IC50 | > | 100000.0 | nM | - |