Assay Detail
Binding
CHEMBL699736
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Inhibitory concentration required to displace [3H]insP3 from Inositol 1,4,5-trisphosphate receptor of bovine adrenal cortex membranes
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Adrenal cortex |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Chemical synthesis and biological evaluation of 1d-1,2,4,5-InsP4 and its 3-fluorinated counterpart 1d-3-F-1,2,4,5-InsP4 potent 1d-1,4,5-InsP3-like calcium mobilizing analogues
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 7.73 | 8.26 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL279107 | INS(1,4,5)P3 | — | 1 | 8.26 |
| CHEMBL3349691 | — | — | 1 | 8.06 |
| CHEMBL1159850 | — | — | 1 | 8.01 |
| CHEMBL1159846 | — | — | 1 | 6.57 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL279107 | INS(1,4,5)P3 | IC50 | = | 5.5 | nM | 8.26 |
| CHEMBL3349691 | — | IC50 | = | 8.7 | nM | 8.06 |
| CHEMBL1159850 | — | IC50 | = | 9.7 | nM | 8.01 |
| CHEMBL1159846 | — | IC50 | = | 268.8 | nM | 6.57 |