Assay Detail
Binding
CHEMBL699737
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Tested for the ability to displace [3H]1,4,5-IP3 from the 1,4,5-IP3 specific binding site of membranes from the bovine adrenal cortices
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Deoxygenated inositol 1,4,5-trisphosphate analogues and their interaction with metabolic enzymes. (1R,2R,4R)-cyclohexane-1,2,4-tris(methylenesulfonate): a potent selective 5-phosphatase inhibitor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 4.90 | 5.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL279107 | INS(1,4,5)P3 | — | 1 | 5.66 |
| CHEMBL1160800 | — | — | 1 | 4.63 |
| CHEMBL1160797 | — | — | 1 | 4.40 |
| CHEMBL1160798 | — | — | 1 | - |
| CHEMBL1160801 | — | — | 1 | - |
| CHEMBL1160811 | — | — | 1 | - |
| CHEMBL2092837 | — | — | 1 | - |
| CHEMBL1160802 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL279107 | INS(1,4,5)P3 | Ki | = | 2200.0 | nM | 5.66 |
| CHEMBL1160800 | — | Ki | = | 23400.0 | nM | 4.63 |
| CHEMBL1160797 | — | Ki | = | 39600.0 | nM | 4.40 |
| CHEMBL1160798 | — | Ki | > | 100000000.0 | nM | - |
| CHEMBL1160801 | — | Ki | = | 3948000.0 | nM | - |
| CHEMBL1160811 | — | Ki | > | 100000000.0 | nM | - |
| CHEMBL2092837 | — | Ki | > | 100000000.0 | nM | - |
| CHEMBL1160802 | — | Ki | > | 100000000.0 | nM | - |