Assay Detail
Binding
CHEMBL699739
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity against Inositol 1,4,5-trisphosphate receptor on bovine adrenal cortex microsomes.
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Adrenal cortex |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Inositol 1,4,5-trisphosphate-gated calcium channel ITPR3 (CHEMBL2853) ↗| Type | SINGLE PROTEIN |
| Organism | Bos taurus |
Publication
Synthesis, acid-base behavior, and binding properties of 6-modified myo-inositol 1,4,5-tris(phosphate)s.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.46 | 6.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL144954 | — | — | 1 | 6.00 |
| CHEMBL18162 | — | — | 1 | 5.70 |
| CHEMBL355920 | — | — | 1 | 5.52 |
| CHEMBL278700 | — | — | 1 | 5.41 |
| CHEMBL145009 | — | — | 1 | 5.30 |
| CHEMBL279107 | INS(1,4,5)P3 | — | 1 | 4.85 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL144954 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL18162 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL355920 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL278700 | — | IC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL145009 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL279107 | INS(1,4,5)P3 | IC50 | = | 14000.0 | nM | 4.85 |