Assay Detail
Binding
CHEMBL699776
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Compound was evaluated for binding affinity at Ionotropic glutamate receptor kainate using [3H]- KAIN as radioligand
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
Glutamate receptor ionotropic, kainate (CHEMBL2094119) ↗| Type | PROTEIN COMPLEX GROUP |
| Organism | Rattus norvegicus |
Publication
Synthesis and pharmacology of a new AMPA-kainate receptor agonist with potent convulsant activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.26 | 8.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL275040 | KAINIC ACID | 2.0 | 1 | 8.15 |
| CHEMBL125440 | — | — | 1 | 6.32 |
| CHEMBL340591 | — | — | 1 | 4.32 |
| CHEMBL276815 | (S)-AMPA | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL275040 | KAINIC ACID | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL125440 | — | IC50 | = | 480.0 | nM | 6.32 |
| CHEMBL340591 | — | IC50 | = | 48000.0 | nM | 4.32 |
| CHEMBL276815 | (S)-AMPA | IC50 | > | 100000.0 | nM | - |