Assay Detail
Binding
CHEMBL699777
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Compound was evaluated for inhibition of binding of [3H]KA to specific binding at Ka receptor in rat cortical membrane
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
Glutamate receptor ionotropic, kainate (CHEMBL2094119) ↗| Type | PROTEIN COMPLEX GROUP |
| Organism | Rattus norvegicus |
Publication
7-Chloro-4,5-dihydro-8-(1,2,4-triazol-4-yl)-4-oxo-1,2,4-triazolo[1, 5-a]quinoxaline-2- carboxylates as novel highly selective AMPA receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 4.96 | 5.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL222519 | NBQX | — | 1 | 5.16 |
| CHEMBL267276 | TQX-173 | — | 1 | 4.94 |
| CHEMBL320952 | — | — | 1 | 4.78 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL222519 | NBQX | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL267276 | TQX-173 | IC50 | = | 11600.0 | nM | 4.94 |
| CHEMBL320952 | — | IC50 | = | 16800.0 | nM | 4.78 |