Assay Detail
Binding
CHEMBL699807
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Inhibition of human neutrophil elastase HNE, hydrolysis of MeO-Suc-Ala-Ala-Pro-Val-pNa
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Design and synthesis of new orally active nonpeptidic inhibitors of human neutrophil elastase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 14 | 8.46 | 10.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL285231 | — | — | 1 | 10.60 |
| CHEMBL24058 | — | — | 1 | 9.31 |
| CHEMBL277672 | — | — | 1 | 9.28 |
| CHEMBL283168 | — | — | 1 | 9.19 |
| CHEMBL279941 | — | — | 1 | 8.93 |
| CHEMBL278134 | — | — | 1 | 8.86 |
| CHEMBL23234 | — | — | 1 | 8.45 |
| CHEMBL282705 | — | — | 1 | 8.20 |
| CHEMBL26499 | — | — | 1 | 7.93 |
| CHEMBL25892 | FRESELESTAT | 2.0 | 1 | 7.92 |
| CHEMBL277401 | — | — | 1 | 7.82 |
| CHEMBL147676 | — | — | 1 | 7.54 |
| CHEMBL22927 | — | — | 1 | 7.35 |
| CHEMBL428848 | — | — | 1 | 7.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL285231 | — | Ki | = | 0.025 | nM | 10.60 |
| CHEMBL24058 | — | Ki | = | 0.49 | nM | 9.31 |
| CHEMBL277672 | — | Ki | = | 0.52 | nM | 9.28 |
| CHEMBL283168 | — | Ki | = | 0.64 | nM | 9.19 |
| CHEMBL279941 | — | Ki | = | 1.18 | nM | 8.93 |
| CHEMBL278134 | — | Ki | = | 1.37 | nM | 8.86 |
| CHEMBL23234 | — | Ki | = | 3.59 | nM | 8.45 |
| CHEMBL282705 | — | Ki | = | 6.38 | nM | 8.20 |
| CHEMBL26499 | — | Ki | = | 11.8 | nM | 7.93 |
| CHEMBL25892 | FRESELESTAT | Ki | = | 12.16 | nM | 7.92 |
| CHEMBL277401 | — | Ki | = | 15.3 | nM | 7.82 |
| CHEMBL147676 | — | Ki | = | 29.1 | nM | 7.54 |
| CHEMBL22927 | — | Ki | = | 44.3 | nM | 7.35 |
| CHEMBL428848 | — | Ki | = | 101.0 | nM | 7.00 |