Assay Detail
Functional
CHEMBL699844
Review assay metadata, readout intent, target linkage, and publication context from the same page.
cell growth inhibition was determined in KB cells in quadruplicate assays
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | KB |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis and antiproliferative and antiviral activity of 2'-deoxy-2'-fluoroarabinofuranosyl analogs of the nucleoside antibiotics toyocamycin and sangivamycin.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.43 | 5.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3143101 | — | — | 1 | 5.72 |
| CHEMBL3143102 | — | — | 1 | 5.52 |
| CHEMBL473686 | — | — | 1 | 5.06 |
| CHEMBL2112691 | — | — | 1 | - |
| CHEMBL2112687 | — | — | 1 | - |
| CHEMBL182 | GANCICLOVIR | 4.0 | 1 | - |
| CHEMBL2111874 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3143101 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL3143102 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL473686 | — | IC50 | = | 8800.0 | nM | 5.06 |
| CHEMBL2112691 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2112687 | — | IC50 | = | 144000.0 | nM | - |
| CHEMBL182 | GANCICLOVIR | IC50 | > | 100000.0 | nM | - |
| CHEMBL2111874 | — | IC50 | > | 150000.0 | nM | - |