Assay Detail
Binding
CHEMBL699983
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory activity against (IMPDH) inosine 5'-monophosphate dehydrogenase
30
Total Activities
30
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Expert |
Target
Inosine-5'-monophosphate dehydrogenase (IMPDH) (CHEMBL2111369) ↗| Type | PROTEIN FAMILY |
| Organism | Homo sapiens |
Publication
Discovery of novel low molecular weight inhibitors of IMPDH via virtual needle screening.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 30 | 5.23 | 7.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL25138 | — | — | 1 | 7.40 |
| CHEMBL24092 | — | — | 1 | 6.75 |
| CHEMBL47928 | — | — | 1 | 6.70 |
| CHEMBL45658 | — | — | 1 | 6.37 |
| CHEMBL46358 | — | — | 1 | 6.33 |
| CHEMBL45504 | — | — | 1 | 6.14 |
| CHEMBL48668 | — | — | 1 | 6.04 |
| CHEMBL47830 | — | — | 1 | 5.92 |
| CHEMBL44696 | — | — | 1 | 5.89 |
| CHEMBL416079 | — | — | 1 | 5.62 |
| CHEMBL47067 | — | — | 1 | 5.36 |
| CHEMBL45771 | — | — | 1 | 5.09 |
| CHEMBL279957 | — | — | 1 | 4.85 |
| CHEMBL432699 | — | — | 1 | 4.82 |
| CHEMBL297980 | — | — | 1 | 4.80 |
| CHEMBL47362 | — | — | 1 | 4.75 |
| CHEMBL45870 | — | — | 1 | 4.72 |
| CHEMBL27985 | — | — | 1 | 4.70 |
| CHEMBL866 | MYCOPHENOLIC ACID | 4.0 | 1 | 4.70 |
| CHEMBL44826 | — | — | 1 | 4.68 |
| CHEMBL296923 | — | — | 1 | 4.57 |
| CHEMBL44551 | — | — | 1 | 4.51 |
| CHEMBL296209 | — | — | 1 | 4.50 |
| CHEMBL46724 | — | — | 1 | 4.50 |
| CHEMBL45230 | — | — | 1 | 4.46 |
| CHEMBL46723 | — | — | 1 | 4.27 |
| CHEMBL45926 | — | — | 1 | 4.06 |
| CHEMBL294926 | — | — | 1 | 4.00 |
| CHEMBL47807 | — | — | 1 | - |
| CHEMBL44789 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL25138 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL24092 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL47928 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL45658 | — | IC50 | = | 430.0 | nM | 6.37 |
| CHEMBL46358 | — | IC50 | = | 470.0 | nM | 6.33 |
| CHEMBL45504 | — | IC50 | = | 730.0 | nM | 6.14 |
| CHEMBL48668 | — | IC50 | = | 910.0 | nM | 6.04 |
| CHEMBL47830 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL44696 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL416079 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL47067 | — | IC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL45771 | — | IC50 | = | 8100.0 | nM | 5.09 |
| CHEMBL279957 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL432699 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL297980 | — | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL47362 | — | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL45870 | — | IC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL27985 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL866 | MYCOPHENOLIC ACID | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL44826 | — | IC50 | = | 21000.0 | nM | 4.68 |
| CHEMBL296923 | — | IC50 | = | 27000.0 | nM | 4.57 |
| CHEMBL44551 | — | IC50 | = | 31000.0 | nM | 4.51 |
| CHEMBL296209 | — | IC50 | = | 32000.0 | nM | 4.50 |
| CHEMBL46724 | — | IC50 | = | 32000.0 | nM | 4.50 |
| CHEMBL45230 | — | IC50 | = | 35000.0 | nM | 4.46 |
| CHEMBL46723 | — | IC50 | = | 54000.0 | nM | 4.27 |
| CHEMBL45926 | — | IC50 | = | 88000.0 | nM | 4.06 |
| CHEMBL294926 | — | IC50 | = | 99000.0 | nM | 4.00 |
| CHEMBL47807 | — | IC50 | = | 620000.0 | nM | - |
| CHEMBL44789 | — | IC50 | = | 168000.0 | nM | - |