Assay Detail
Binding
CHEMBL699984
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Inosine Monophosphate Dehydrogenase II (IMPDH II)
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Inosine-5'-monophosphate dehydrogenase 2 (CHEMBL2002) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
A survey of cyclic replacements for the central diamide moiety of inhibitors of inosine monophosphate dehydrogenase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 7.02 | 7.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL866 | MYCOPHENOLIC ACID | 4.0 | 1 | 7.82 |
| CHEMBL64639 | — | — | 1 | 7.70 |
| CHEMBL68221 | — | — | 1 | 7.39 |
| CHEMBL420288 | — | — | 1 | 7.36 |
| CHEMBL283256 | — | — | 1 | 7.28 |
| CHEMBL104051 | — | — | 1 | 7.23 |
| CHEMBL104535 | — | — | 1 | 6.96 |
| CHEMBL104313 | — | — | 1 | 6.96 |
| CHEMBL107337 | — | — | 1 | 6.92 |
| CHEMBL307547 | — | — | 1 | 6.82 |
| CHEMBL104240 | — | — | 1 | 6.72 |
| CHEMBL104739 | — | — | 1 | 6.52 |
| CHEMBL104282 | — | — | 1 | 6.48 |
| CHEMBL104710 | — | — | 1 | 6.12 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL866 | MYCOPHENOLIC ACID | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL64639 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL68221 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL420288 | — | IC50 | = | 44.0 | nM | 7.36 |
| CHEMBL283256 | — | IC50 | = | 52.0 | nM | 7.28 |
| CHEMBL104051 | — | IC50 | = | 59.0 | nM | 7.23 |
| CHEMBL104535 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL104313 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL107337 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL307547 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL104240 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL104739 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL104282 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL104710 | — | IC50 | = | 760.0 | nM | 6.12 |