Assay Detail
Binding
CHEMBL699987
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Inhibitory concentration against Recombinant HIV-1 integrase (3'processing)
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Human immunodeficiency virus type 1 integrase (CHEMBL3471) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
Azido-containing aryl beta-diketo acid HIV-1 integrase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 4.12 | 4.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL278545 | — | — | 1 | 4.16 |
| CHEMBL18927 | — | — | 1 | 4.07 |
| CHEMBL20592 | — | — | 1 | - |
| CHEMBL19977 | — | — | 1 | - |
| CHEMBL20091 | — | — | 1 | - |
| CHEMBL20117 | — | — | 1 | - |
| CHEMBL20586 | — | — | 1 | - |
| CHEMBL20758 | — | — | 1 | - |
| CHEMBL20342 | — | — | 1 | - |
| CHEMBL20378 | — | — | 1 | - |
| CHEMBL20702 | — | — | 1 | - |
| CHEMBL20633 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL278545 | — | IC50 | = | 70000.0 | nM | 4.16 |
| CHEMBL18927 | — | IC50 | = | 85000.0 | nM | 4.07 |
| CHEMBL20592 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL19977 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL20091 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL20117 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL20586 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL20758 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL20342 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL20378 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL20702 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL20633 | — | IC50 | > | 100000.0 | nM | - |