Assay Detail
Functional
CHEMBL700010
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro cytotoxicity against human cancerous neuroblastoma cells (IMR-32)
28
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | IMR-32 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Examination of the 1,4-disubstituted azetidinone ring system as a template for combretastatin A-4 conformationally restricted analogue design.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 28 | 6.85 | 7.48 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL64318 | — | — | 1 | 7.48 |
| CHEMBL416673 | — | — | 2 | 7.43 |
| CHEMBL293834 | — | — | 2 | 7.42 |
| CHEMBL61102 | — | — | 1 | 7.14 |
| CHEMBL304898 | — | — | 1 | 7.05 |
| CHEMBL302389 | — | — | 1 | 6.91 |
| CHEMBL64330 | — | — | 1 | 6.60 |
| CHEMBL65633 | — | — | 2 | 6.35 |
| CHEMBL60906 | — | — | 1 | 6.28 |
| CHEMBL61903 | — | — | 1 | 6.09 |
| CHEMBL293199 | — | — | 1 | 6.04 |
| CHEMBL64412 | — | — | 1 | - |
| CHEMBL293028 | — | — | 1 | - |
| CHEMBL64038 | — | — | 1 | - |
| CHEMBL63079 | — | — | 2 | - |
| CHEMBL62929 | — | — | 1 | - |
| CHEMBL418126 | — | — | 1 | - |
| CHEMBL62749 | — | — | 1 | - |
| CHEMBL65020 | — | — | 1 | - |
| CHEMBL64186 | — | — | 2 | - |
| CHEMBL62516 | — | — | 1 | - |
| CHEMBL64856 | — | — | 1 | - |
| CHEMBL61101 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL64318 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL416673 | — | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL416673 | — | IC50 | = | 38.3 | nM | 7.42 |
| CHEMBL293834 | — | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL293834 | — | IC50 | = | 41.4 | nM | 7.38 |
| CHEMBL61102 | — | IC50 | = | 73.09 | nM | 7.14 |
| CHEMBL304898 | — | IC50 | = | 89.0 | nM | 7.05 |
| CHEMBL302389 | — | IC50 | = | 123.3 | nM | 6.91 |
| CHEMBL64330 | — | IC50 | = | 251.0 | nM | 6.60 |
| CHEMBL65633 | — | IC50 | = | 444.7 | nM | 6.35 |
| CHEMBL65633 | — | IC50 | = | 473.0 | nM | 6.33 |
| CHEMBL60906 | — | IC50 | = | 520.0 | nM | 6.28 |
| CHEMBL61903 | — | IC50 | = | 811.0 | nM | 6.09 |
| CHEMBL293199 | — | IC50 | = | 910.0 | nM | 6.04 |
| CHEMBL64038 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL63079 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL63079 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL61101 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL293028 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL418126 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL65020 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL64186 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL64186 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL64412 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL62516 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL64856 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL62929 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL62749 | — | IC50 | > | 1000.0 | nM | - |