Assay Detail
Binding
CHEMBL700067
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Binding affinity against L-type calcium channel verapamil site
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Voltage-gated L-type calcium channel (CHEMBL2095229) ↗| Type | PROTEIN FAMILY |
| Organism | Homo sapiens |
Publication
From hit to lead. Analyzing structure-profile relationships.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 5.83 | 6.55 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL116463 | — | — | 1 | 6.55 |
| CHEMBL115280 | — | — | 1 | 6.26 |
| CHEMBL113956 | — | — | 1 | 6.07 |
| CHEMBL115652 | — | — | 1 | 5.96 |
| CHEMBL326263 | — | — | 1 | 5.76 |
| CHEMBL117537 | — | — | 1 | 5.63 |
| CHEMBL325516 | — | — | 1 | 5.56 |
| CHEMBL116735 | — | — | 1 | 5.37 |
| CHEMBL420499 | — | — | 1 | 5.32 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL116463 | — | IC50 | = | 284.0 | nM | 6.55 |
| CHEMBL115280 | — | IC50 | = | 552.0 | nM | 6.26 |
| CHEMBL113956 | — | IC50 | = | 860.0 | nM | 6.07 |
| CHEMBL115652 | — | IC50 | = | 1110.0 | nM | 5.96 |
| CHEMBL326263 | — | IC50 | = | 1720.0 | nM | 5.76 |
| CHEMBL117537 | — | IC50 | = | 2350.0 | nM | 5.63 |
| CHEMBL325516 | — | IC50 | = | 2730.0 | nM | 5.56 |
| CHEMBL116735 | — | IC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL420499 | — | IC50 | = | 4840.0 | nM | 5.32 |