Assay Detail
Binding
CHEMBL700070
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of [3H]diltiazem binding to L-type [Ca2+] channel in rabbit skeletal muscle
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Oryctolagus cuniculus |
| Tissue | Muscle tissue |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
2(S)-((3,5-bis(trifluoromethyl)benzyl)-oxy)-3(S)-phenyl-4- ((3-oxo-1,2,4-triazol-5-yl)methyl)morpholine (1): a potent, orally active, morpholine-based human neurokinin-1 receptor antagonist.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 5.18 | 5.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL441225 | CP-99994 | — | 1 | 5.40 |
| CHEMBL52330 | — | — | 1 | 4.96 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL441225 | CP-99994 | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL52330 | — | IC50 | = | 11000.0 | nM | 4.96 |