Assay Detail
Binding
CHEMBL700076
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of [3H]D-888 binding to L-type [Ca2+] channel of membranes from rat skeletal muscle
33
Total Activities
32
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Muscle tissue |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Voltage-dependent L-type calcium channel subunit alpha-1S (CHEMBL4108) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
New purines and purine analogs as modulators of multidrug resistance.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 33 | 6.69 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL335742 | — | — | 1 | 8.30 |
| CHEMBL334400 | — | — | 1 | 7.92 |
| CHEMBL341462 | — | — | 1 | 7.34 |
| CHEMBL134195 | — | — | 1 | 7.32 |
| CHEMBL132844 | — | — | 1 | 7.21 |
| CHEMBL130086 | — | — | 1 | 7.21 |
| CHEMBL336375 | — | — | 1 | 7.08 |
| CHEMBL338787 | — | — | 1 | 7.06 |
| CHEMBL132000 | — | — | 1 | 7.05 |
| CHEMBL85156 | — | — | 1 | 7.05 |
| CHEMBL443810 | — | — | 1 | 7.03 |
| CHEMBL336560 | — | — | 1 | 7.00 |
| CHEMBL341438 | — | — | 1 | 6.96 |
| CHEMBL130248 | — | — | 1 | 6.92 |
| CHEMBL133118 | — | — | 1 | 6.77 |
| CHEMBL132565 | — | — | 1 | 6.77 |
| CHEMBL438385 | — | — | 1 | 6.70 |
| CHEMBL133458 | — | — | 1 | 6.57 |
| CHEMBL133062 | — | — | 1 | 6.40 |
| CHEMBL336350 | — | — | 1 | 6.39 |
| CHEMBL130301 | — | — | 1 | 6.38 |
| CHEMBL337019 | — | — | 1 | 6.36 |
| CHEMBL337682 | — | — | 1 | 6.31 |
| CHEMBL132911 | — | — | 1 | 6.26 |
| CHEMBL424637 | — | — | 1 | 6.25 |
| CHEMBL133567 | — | — | 1 | 6.21 |
| CHEMBL133781 | — | — | 1 | 6.20 |
| CHEMBL340348 | — | — | 2 | 6.19 |
| CHEMBL130484 | — | — | 1 | 6.11 |
| CHEMBL131847 | — | — | 1 | 6.07 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL335742 | — | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL334400 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL341462 | — | Ki | = | 46.0 | nM | 7.34 |
| CHEMBL134195 | — | Ki | = | 48.0 | nM | 7.32 |
| CHEMBL132844 | — | Ki | = | 62.0 | nM | 7.21 |
| CHEMBL130086 | — | Ki | = | 62.0 | nM | 7.21 |
| CHEMBL336375 | — | Ki | = | 84.0 | nM | 7.08 |
| CHEMBL338787 | — | Ki | = | 87.0 | nM | 7.06 |
| CHEMBL132000 | — | Ki | = | 90.0 | nM | 7.05 |
| CHEMBL85156 | — | Ki | = | 89.0 | nM | 7.05 |
| CHEMBL443810 | — | Ki | = | 93.0 | nM | 7.03 |
| CHEMBL336560 | — | Ki | = | 99.0 | nM | 7.00 |
| CHEMBL341438 | — | Ki | = | 110.0 | nM | 6.96 |
| CHEMBL130248 | — | Ki | = | 120.0 | nM | 6.92 |
| CHEMBL132565 | — | Ki | = | 170.0 | nM | 6.77 |
| CHEMBL133118 | — | Ki | = | 170.0 | nM | 6.77 |
| CHEMBL438385 | — | Ki | = | 200.0 | nM | 6.70 |
| CHEMBL133458 | — | Ki | = | 270.0 | nM | 6.57 |
| CHEMBL133062 | — | Ki | = | 400.0 | nM | 6.40 |
| CHEMBL336350 | — | Ki | = | 410.0 | nM | 6.39 |
| CHEMBL130301 | — | Ki | = | 420.0 | nM | 6.38 |
| CHEMBL337019 | — | Ki | = | 440.0 | nM | 6.36 |
| CHEMBL337682 | — | Ki | = | 490.0 | nM | 6.31 |
| CHEMBL132911 | — | Ki | = | 550.0 | nM | 6.26 |
| CHEMBL424637 | — | Ki | = | 560.0 | nM | 6.25 |
| CHEMBL133567 | — | Ki | = | 620.0 | nM | 6.21 |
| CHEMBL133781 | — | Ki | = | 630.0 | nM | 6.20 |
| CHEMBL340348 | — | Ki | = | 650.0 | nM | 6.19 |
| CHEMBL130484 | — | Ki | = | 770.0 | nM | 6.11 |
| CHEMBL131847 | — | Ki | = | 860.0 | nM | 6.07 |
| CHEMBL340348 | — | Ki | = | 1000.0 | nM | 6.00 |
| CHEMBL132637 | — | Ki | = | 1600.0 | nM | 5.80 |
| CHEMBL132782 | — | Ki | = | 3700.0 | nM | 5.43 |