Assay Detail
Functional
CHEMBL700122
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Concentration required to elicit ganglionic receptors measured using [86Rb+] flux functional assay in a human neuroblastoma-derived IMR-32 cell line
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | IMR-32 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Structure-activity studies on 2-methyl-3-(2(S)-pyrrolidinylmethoxy) pyridine (ABT-089): an orally bioavailable 3-pyridyl ether nicotinic acetylcholine receptor ligand with cognition-enhancing properties.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 6 | 4.39 | 4.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3 | NICOTINE | 4.0 | 1 | 4.68 |
| CHEMBL84692 | — | — | 1 | 4.60 |
| CHEMBL126692 | — | — | 1 | 4.30 |
| CHEMBL84149 | — | — | 1 | 4.20 |
| CHEMBL274525 | ABT-418 | — | 1 | 4.19 |
| CHEMBL127071 | POZANICLINE | 2.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3 | NICOTINE | EC50 | = | 21000.0 | nM | 4.68 |
| CHEMBL84692 | — | EC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL126692 | — | EC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL84149 | — | EC50 | = | 63000.0 | nM | 4.20 |
| CHEMBL274525 | ABT-418 | EC50 | = | 64000.0 | nM | 4.19 |
| CHEMBL127071 | POZANICLINE | EC50 | = | 150000.0 | nM | - |