Assay Detail
Functional
CHEMBL700205
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In vitro cytotoxicity tested against human chronic leukemia K562 cells
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | K562 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Cross-linking and sequence specific alkylation of DNA by aziridinyl quinones. 2. Structure requirements for sequence selectivity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 22 | 7.58 | 8.74 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL311910 | — | — | 1 | 8.74 |
| CHEMBL313302 | TRIAZIQUONE | 2.0 | 1 | 8.54 |
| CHEMBL121276 | — | — | 1 | 8.51 |
| CHEMBL120660 | — | — | 1 | 8.32 |
| CHEMBL333338 | — | — | 1 | 8.28 |
| CHEMBL121205 | — | — | 1 | 8.24 |
| CHEMBL119218 | — | — | 1 | 8.14 |
| CHEMBL72536 | — | — | 1 | 8.08 |
| CHEMBL121453 | — | — | 1 | 8.00 |
| CHEMBL120469 | — | — | 1 | 7.90 |
| CHEMBL331338 | — | — | 1 | 7.41 |
| CHEMBL120912 | — | — | 1 | 7.38 |
| CHEMBL120756 | — | — | 1 | 7.34 |
| CHEMBL122412 | — | — | 1 | 7.30 |
| CHEMBL36016 | DIAZIQUONE | 2.0 | 1 | 7.20 |
| CHEMBL86403 | — | — | 1 | 7.17 |
| CHEMBL119931 | — | — | 1 | 7.12 |
| CHEMBL332840 | — | — | 1 | 6.80 |
| CHEMBL120815 | — | — | 1 | 6.77 |
| CHEMBL122013 | — | — | 1 | 6.67 |
| CHEMBL120541 | — | — | 1 | 6.62 |
| CHEMBL120194 | — | — | 1 | 6.32 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL311910 | — | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL313302 | TRIAZIQUONE | IC50 | = | 2.9 | nM | 8.54 |
| CHEMBL121276 | — | IC50 | = | 3.1 | nM | 8.51 |
| CHEMBL120660 | — | IC50 | = | 4.8 | nM | 8.32 |
| CHEMBL333338 | — | IC50 | = | 5.3 | nM | 8.28 |
| CHEMBL121205 | — | IC50 | = | 5.8 | nM | 8.24 |
| CHEMBL119218 | — | IC50 | = | 7.3 | nM | 8.14 |
| CHEMBL72536 | — | IC50 | = | 8.3 | nM | 8.08 |
| CHEMBL121453 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL120469 | — | IC50 | = | 12.6 | nM | 7.90 |
| CHEMBL331338 | — | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL120912 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL120756 | — | IC50 | = | 46.0 | nM | 7.34 |
| CHEMBL122412 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL36016 | DIAZIQUONE | IC50 | = | 63.0 | nM | 7.20 |
| CHEMBL86403 | — | IC50 | = | 67.0 | nM | 7.17 |
| CHEMBL119931 | — | IC50 | = | 76.0 | nM | 7.12 |
| CHEMBL332840 | — | IC50 | = | 158.0 | nM | 6.80 |
| CHEMBL120815 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL122013 | — | IC50 | = | 216.0 | nM | 6.67 |
| CHEMBL120541 | — | IC50 | = | 239.0 | nM | 6.62 |
| CHEMBL120194 | — | IC50 | = | 476.0 | nM | 6.32 |