Assay Detail
Functional
CHEMBL700210
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory activity against K562 human chronic myelogenous leukemia cell line using MTT assay after 5 days incubation of the compound
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | K562 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
The total synthesis of an aurone isolated from Uvaria hamiltonii: aurones and flavones as anticancer agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 6.23 | 9.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL9859 | — | — | 1 | 9.70 |
| CHEMBL123092 | — | — | 1 | 7.40 |
| CHEMBL126094 | — | — | 1 | 7.30 |
| CHEMBL125287 | — | — | 1 | 6.96 |
| CHEMBL124773 | — | — | 1 | 6.82 |
| CHEMBL122479 | — | — | 1 | 6.82 |
| CHEMBL122974 | — | — | 1 | 6.23 |
| CHEMBL125530 | — | — | 1 | 6.08 |
| CHEMBL123786 | — | — | 1 | 5.01 |
| CHEMBL124392 | — | — | 1 | 4.92 |
| CHEMBL122075 | — | — | 1 | 4.75 |
| CHEMBL124885 | — | — | 1 | 4.66 |
| CHEMBL75349 | TETRAMETHYLSCUTELLAREIN | — | 1 | 4.38 |
| CHEMBL339935 | — | — | 1 | - |
| CHEMBL125757 | — | — | 1 | - |
| CHEMBL125430 | — | — | 1 | - |
| CHEMBL122964 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL9859 | — | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL123092 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL126094 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL125287 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL124773 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL122479 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL122974 | — | IC50 | = | 590.0 | nM | 6.23 |
| CHEMBL125530 | — | IC50 | = | 830.0 | nM | 6.08 |
| CHEMBL123786 | — | IC50 | = | 9700.0 | nM | 5.01 |
| CHEMBL124392 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL122075 | — | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL124885 | — | IC50 | = | 22000.0 | nM | 4.66 |
| CHEMBL75349 | TETRAMETHYLSCUTELLAREIN | IC50 | = | 42000.0 | nM | 4.38 |
| CHEMBL339935 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL125757 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL125430 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL122964 | — | IC50 | > | 50000.0 | nM | - |