Assay Detail
Functional
CHEMBL700213
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Inhibitory concentration against human K562 leukemia cells following incubation for 1 hour
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | K562 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Linker length modulates DNA cross-linking reactivity and cytotoxic potency of C8/C8' ether-linked C2-exo-unsaturated pyrrolo[2,1-c][1,4]benzodiazepine (PBD) dimers.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.79 | 7.37 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL16498 | SJG-136 | 2.0 | 1 | 7.37 |
| CHEMBL279754 | DSB-120 | — | 1 | 6.70 |
| CHEMBL17005 | — | — | 1 | 6.30 |
| CHEMBL16932 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL16498 | SJG-136 | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL279754 | DSB-120 | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL17005 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL16932 | — | IC50 | < | 1.0 | nM | - |