Assay Detail
Functional
CHEMBL700224
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Inhibition of K562 leukemia cell proliferation
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | K562 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
7-Alkoxy-4-phenylamino-3-quinolinecar-bonitriles as dual inhibitors of Src and Abl kinases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 7.26 | 7.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL290921 | — | — | 1 | 7.75 |
| CHEMBL288441 | BOSUTINIB | 4.0 | 1 | 7.70 |
| CHEMBL42136 | — | — | 1 | 7.41 |
| CHEMBL440847 | — | — | 1 | 6.85 |
| CHEMBL43577 | — | — | 1 | 6.58 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL290921 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL288441 | BOSUTINIB | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL42136 | — | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL440847 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL43577 | — | IC50 | = | 260.0 | nM | 6.58 |