Assay Detail
Binding
CHEMBL700241
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Tested in vitro for inhibition of KDR-receptor tyrosine kinase
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Vascular endothelial growth factor receptor 2 (CHEMBL279) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Substituted 5,7-diphenyl-pyrrolo[2,3d]pyrimidines: potent inhibitors of the tyrosine kinase c-Src.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 6.10 | 6.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL176705 | — | — | 1 | 6.70 |
| CHEMBL169757 | — | — | 1 | 6.30 |
| CHEMBL367442 | — | — | 1 | 6.22 |
| CHEMBL176309 | — | — | 1 | 6.00 |
| CHEMBL369014 | — | — | 1 | 5.96 |
| CHEMBL176702 | — | — | 1 | 5.44 |
| CHEMBL172973 | — | — | 1 | - |
| CHEMBL105436 | — | — | 1 | - |
| CHEMBL175409 | — | — | 1 | - |
| CHEMBL176815 | — | — | 1 | - |
| CHEMBL424375 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL176705 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL169757 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL367442 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL176309 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL369014 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL176702 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL172973 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL105436 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL175409 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL176815 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL424375 | — | IC50 | > | 1000.0 | nM | - |