Assay Detail
Functional
CHEMBL700295
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Ability to stimulate Rb+ efflux from human IMR-32 cell preparations containing human alpha3-betaX receptors
9
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | IMR-32 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Novel 3-Pyridyl ethers with subnanomolar affinity for central neuronal nicotinic acetylcholine receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 9 | 5.36 | 8.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL6623 | EPIBATIDINE | — | 1 | 8.15 |
| CHEMBL59986 | — | — | 1 | 6.16 |
| CHEMBL262769 | — | — | 1 | 5.96 |
| CHEMBL440195 | — | — | 1 | 5.24 |
| CHEMBL84149 | — | — | 2 | 4.92 |
| CHEMBL3 | NICOTINE | 4.0 | 1 | 4.68 |
| CHEMBL293435 | — | — | 1 | 4.52 |
| CHEMBL168780 | — | — | 1 | 4.42 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL6623 | EPIBATIDINE | EC50 | = | 7.0 | nM | 8.15 |
| CHEMBL59986 | — | EC50 | = | 700.0 | nM | 6.16 |
| CHEMBL262769 | — | EC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL440195 | — | EC50 | = | 5800.0 | nM | 5.24 |
| CHEMBL84149 | — | EC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL3 | NICOTINE | EC50 | = | 21000.0 | nM | 4.68 |
| CHEMBL293435 | — | EC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL168780 | — | EC50 | = | 38000.0 | nM | 4.42 |
| CHEMBL84149 | — | EC50 | = | 63000.0 | nM | 4.20 |