Assay Detail
Binding
CHEMBL700338
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Binding affinity against Ionotropic glutamate receptor kainate using [3H]KAIN as radioligand.
10
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
Glutamate receptor ionotropic, kainate (CHEMBL2094119) ↗| Type | PROTEIN COMPLEX GROUP |
| Organism | Rattus norvegicus |
Publication
Synthesis and enantiopharmacology of new AMPA-kainate receptor agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 5.58 | 8.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL275040 | KAINIC ACID | 2.0 | 1 | 8.15 |
| CHEMBL125440 | — | — | 3 | 6.64 |
| CHEMBL334583 | — | — | 1 | 5.10 |
| CHEMBL133337 | — | — | 1 | 4.34 |
| CHEMBL340591 | — | — | 3 | 4.32 |
| CHEMBL276815 | (S)-AMPA | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL275040 | KAINIC ACID | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL125440 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL125440 | — | IC50 | = | 480.0 | nM | 6.32 |
| CHEMBL334583 | — | IC50 | = | 7900.0 | nM | 5.10 |
| CHEMBL133337 | — | IC50 | = | 45300.0 | nM | 4.34 |
| CHEMBL340591 | — | IC50 | = | 48000.0 | nM | 4.32 |
| CHEMBL340591 | — | IC50 | = | 67000.0 | nM | 4.17 |
| CHEMBL276815 | (S)-AMPA | IC50 | > | 100000.0 | nM | - |
| CHEMBL340591 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL125440 | — | IC50 | > | 100000.0 | nM | - |