Assay Detail
Functional
CHEMBL700422
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Evaluated for 50% inhibition of growth of L1210 / R81 cells (48 h), relative to untreated controls
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | L1210 ( R81) |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Chemistry and antitumor evaluation of selected classical 2,4-diaminoquinazoline analogues of folic acid.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 4.45 | 4.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL304397 | — | — | 1 | 4.64 |
| CHEMBL423123 | — | — | 1 | 4.38 |
| CHEMBL305177 | — | — | 1 | 4.34 |
| CHEMBL303654 | — | — | 1 | - |
| CHEMBL34259 | METHOTREXATE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL304397 | — | IC50 | = | 23000.0 | nM | 4.64 |
| CHEMBL423123 | — | IC50 | = | 42000.0 | nM | 4.38 |
| CHEMBL305177 | — | IC50 | = | 46000.0 | nM | 4.34 |
| CHEMBL303654 | — | IC50 | > | 101000.0 | nM | - |
| CHEMBL34259 | METHOTREXATE | IC50 | = | 205000.0 | nM | - |