Assay Detail
Functional
CHEMBL700521
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Antiproliferative activity against K562 erythroid leukemic cells was determined.
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | K562 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis of nonhydrolyzable analogues of thiazole-4-carboxamide and benzamide adenine dinucleotide containing fluorine atom at the C2' of adenine nucleoside: induction of K562 differentiation and inosine monophosphate dehydrogenase inhibitory activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 4.98 | 5.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL108358 | TIAZOFURIN | 2.0 | 1 | 5.52 |
| CHEMBL3144026 | — | — | 1 | 5.50 |
| CHEMBL2364562 | — | — | 1 | 5.43 |
| CHEMBL2092769 | — | — | 1 | 5.42 |
| CHEMBL3144028 | — | — | 1 | 4.96 |
| CHEMBL3144061 | — | — | 1 | 4.89 |
| CHEMBL3144029 | — | — | 1 | 4.75 |
| CHEMBL3144007 | — | — | 1 | 4.17 |
| CHEMBL3144062 | — | — | 1 | 4.16 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL108358 | TIAZOFURIN | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL3144026 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL2364562 | — | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL2092769 | — | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL3144028 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL3144061 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL3144029 | — | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL3144007 | — | IC50 | = | 68000.0 | nM | 4.17 |
| CHEMBL3144062 | — | IC50 | = | 70000.0 | nM | 4.16 |