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Assay Detail

CHEMBL700572

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition against Inositol (3,4,5,6)P4 1-kinase from bovine aorta
15
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Bos taurus
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

Synthesis and biological activity of D- and L-chiro-inositol 2,3,4,5-tetrakisphosphate: design of a novel and potent inhibitor of Ins(3,4,5,6)P4 1-kinase/Ins(1,3,4)P3 5/6-kinase.
Liu C, Riley AM, Yang X, Shears SB, Potter BV.
J Med Chem (2001) 44 : 2984 -2989
PubMed 11520207 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 15 5.43 6.77

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1160774 2 6.77
CHEMBL1160775 1 6.16
CHEMBL3351091 2 5.82
CHEMBL1160778 1 5.38
CHEMBL23552 2 5.05
CHEMBL1160784 1 4.84
CHEMBL1160782 IONOSITOL (1,3,4,5,6) P5 1 4.82
CHEMBL1160777 1 4.77
CHEMBL279107 INS(1,4,5)P3 1 4.32
CHEMBL3349661 1 -
CHEMBL3350077 1 -
CHEMBL1160776 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1160774 IC50 = 170.0 nM 6.77
CHEMBL1160774 IC50 = 200.0 nM 6.70
CHEMBL1160775 IC50 = 700.0 nM 6.16
CHEMBL3351091 IC50 = 1500.0 nM 5.82
CHEMBL3351091 IC50 = 1600.0 nM 5.80
CHEMBL1160778 IC50 = 4200.0 nM 5.38
CHEMBL23552 IC50 = 9000.0 nM 5.05
CHEMBL1160784 IC50 = 14500.0 nM 4.84
CHEMBL1160782 IONOSITOL (1,3,4,5,6) P5 IC50 = 15000.0 nM 4.82
CHEMBL23552 IC50 = 16700.0 nM 4.78
CHEMBL1160777 IC50 = 17000.0 nM 4.77
CHEMBL279107 INS(1,4,5)P3 IC50 = 48000.0 nM 4.32
CHEMBL3349661 IC50 > 30000.0 nM -
CHEMBL3350077 IC50 > 30000.0 nM -
CHEMBL1160776 IC50 > 30000.0 nM -