Assay Detail
Functional
CHEMBL700638
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Inhibition of PDGF-induced mitogenesis in human foreskin fibroblasts
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HFF |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Structural studies on bioactive compounds. 23. Synthesis of polyhydroxylated 2-phenylbenzothiazoles and a comparison of their cytotoxicities and pharmacological properties with genistein and quercetin.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 4.37 | 4.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL44227 | — | — | 1 | 4.85 |
| CHEMBL45564 | — | — | 1 | 4.70 |
| CHEMBL48085 | — | — | 1 | 4.17 |
| CHEMBL47966 | — | — | 1 | 4.12 |
| CHEMBL50 | QUERCETIN | 3.0 | 1 | 4.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL44227 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL45564 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL48085 | — | IC50 | = | 68000.0 | nM | 4.17 |
| CHEMBL47966 | — | IC50 | = | 75000.0 | nM | 4.12 |
| CHEMBL50 | QUERCETIN | IC50 | = | 100000.0 | nM | 4.00 |