Assay Detail
Functional
CHEMBL700679
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Evaluated in vitro for the inhibition of Adenosine (ADO) phosphorylation in intact IMR-32 human neuroblastoma cells.
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | IMR-32 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Design, synthesis, and structure-activity relationship of 6-alkynylpyrimidines as potent adenosine kinase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 6.79 | 8.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL338508 | — | — | 1 | 8.15 |
| CHEMBL121182 | — | — | 1 | 7.34 |
| CHEMBL434792 | — | — | 1 | 7.03 |
| CHEMBL121415 | — | — | 1 | 7.03 |
| CHEMBL121361 | — | — | 1 | 7.00 |
| CHEMBL121623 | — | — | 1 | 6.93 |
| CHEMBL120976 | — | — | 1 | 6.91 |
| CHEMBL120984 | — | — | 1 | 6.84 |
| CHEMBL120953 | — | — | 1 | 6.70 |
| CHEMBL331778 | — | — | 1 | 6.55 |
| CHEMBL121475 | — | — | 1 | 6.41 |
| CHEMBL420879 | — | — | 1 | 6.16 |
| CHEMBL332689 | — | — | 1 | 6.00 |
| CHEMBL120650 | — | — | 1 | 6.00 |
| CHEMBL119839 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL338508 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL121182 | — | IC50 | = | 46.0 | nM | 7.34 |
| CHEMBL434792 | — | IC50 | = | 94.0 | nM | 7.03 |
| CHEMBL121415 | — | IC50 | = | 94.0 | nM | 7.03 |
| CHEMBL121361 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL121623 | — | IC50 | = | 118.0 | nM | 6.93 |
| CHEMBL120976 | — | IC50 | = | 124.0 | nM | 6.91 |
| CHEMBL120984 | — | IC50 | = | 146.0 | nM | 6.84 |
| CHEMBL120953 | — | IC50 | = | 198.0 | nM | 6.70 |
| CHEMBL331778 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL121475 | — | IC50 | = | 388.0 | nM | 6.41 |
| CHEMBL420879 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL332689 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL120650 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL119839 | — | IC50 | > | 1000.0 | nM | - |