Assay Detail
Binding
CHEMBL700768
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to the human histamine H4 receptor
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
The first potent and selective non-imidazole human histamine H4 receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 7.27 | 7.91 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL12608 | IMPROMIDINE | 2.0 | 1 | 7.91 |
| CHEMBL260374 | THIOPERAMIDE | — | 1 | 7.57 |
| CHEMBL268229 | — | — | 1 | 6.84 |
| CHEMBL12160 | BURIMAMIDE | — | 1 | 6.75 |
| CHEMBL129257 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL12608 | IMPROMIDINE | Ki | = | 12.3 | nM | 7.91 |
| CHEMBL260374 | THIOPERAMIDE | Ki | = | 27.0 | nM | 7.57 |
| CHEMBL268229 | — | Ki | = | 146.0 | nM | 6.84 |
| CHEMBL12160 | BURIMAMIDE | Ki | = | 180.0 | nM | 6.75 |
| CHEMBL129257 | — | Ki | > | 10000.0 | nM | - |