Assay Detail
Binding
CHEMBL700770
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Displacement of [3H]- histamine from the recombinant human histamine H4 receptor
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
The first potent and selective non-imidazole human histamine H4 receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 24 | 7.32 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL129198 | JNJ-7777120 | — | 1 | 8.40 |
| CHEMBL129436 | — | — | 1 | 8.30 |
| CHEMBL129488 | — | — | 1 | 8.15 |
| CHEMBL129540 | — | — | 1 | 8.10 |
| CHEMBL128613 | — | — | 1 | 8.10 |
| CHEMBL338937 | — | — | 1 | 7.96 |
| CHEMBL129444 | — | — | 1 | 7.85 |
| CHEMBL340740 | — | — | 1 | 7.82 |
| CHEMBL436381 | — | — | 1 | 7.82 |
| CHEMBL129199 | — | — | 1 | 7.77 |
| CHEMBL338051 | — | — | 1 | 7.72 |
| CHEMBL128958 | — | — | 1 | 7.64 |
| CHEMBL129026 | — | — | 1 | 7.51 |
| CHEMBL128505 | — | — | 1 | 7.50 |
| CHEMBL129660 | — | — | 1 | 7.42 |
| CHEMBL128088 | — | — | 1 | 7.34 |
| CHEMBL128252 | — | — | 1 | 7.21 |
| CHEMBL338001 | — | — | 1 | 6.83 |
| CHEMBL341087 | — | — | 1 | 6.70 |
| CHEMBL128134 | — | — | 1 | 6.58 |
| CHEMBL128637 | — | — | 1 | 5.52 |
| CHEMBL128470 | — | — | 1 | 5.16 |
| CHEMBL339826 | — | — | 1 | 5.00 |
| CHEMBL128506 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL129198 | JNJ-7777120 | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL129436 | — | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL129488 | — | Ki | = | 7.0 | nM | 8.15 |
| CHEMBL129540 | — | Ki | = | 8.0 | nM | 8.10 |
| CHEMBL128613 | — | Ki | = | 8.0 | nM | 8.10 |
| CHEMBL338937 | — | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL129444 | — | Ki | = | 14.0 | nM | 7.85 |
| CHEMBL340740 | — | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL436381 | — | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL129199 | — | Ki | = | 17.0 | nM | 7.77 |
| CHEMBL338051 | — | Ki | = | 19.0 | nM | 7.72 |
| CHEMBL128958 | — | Ki | = | 23.0 | nM | 7.64 |
| CHEMBL129026 | — | Ki | = | 31.0 | nM | 7.51 |
| CHEMBL128505 | — | Ki | = | 32.0 | nM | 7.50 |
| CHEMBL129660 | — | Ki | = | 38.0 | nM | 7.42 |
| CHEMBL128088 | — | Ki | = | 46.0 | nM | 7.34 |
| CHEMBL128252 | — | Ki | = | 61.0 | nM | 7.21 |
| CHEMBL338001 | — | Ki | = | 147.0 | nM | 6.83 |
| CHEMBL341087 | — | Ki | = | 202.0 | nM | 6.70 |
| CHEMBL128134 | — | Ki | = | 260.0 | nM | 6.58 |
| CHEMBL128637 | — | Ki | = | 3000.0 | nM | 5.52 |
| CHEMBL128470 | — | Ki | = | 7000.0 | nM | 5.16 |
| CHEMBL339826 | — | Ki | = | 10000.0 | nM | 5.00 |
| CHEMBL128506 | — | Ki | > | 10000.0 | nM | - |