Assay Detail
Functional
CHEMBL700815
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Evaluated for the growth inhibition of L1210 /S cells
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | L1210 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Chemistry and antitumor evaluation of selected classical 2,4-diaminoquinazoline analogues of folic acid.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 6.70 | 7.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL34259 | METHOTREXATE | 4.0 | 1 | 7.92 |
| CHEMBL304397 | — | — | 1 | 7.77 |
| CHEMBL305177 | — | — | 1 | 7.68 |
| CHEMBL305253 | — | — | 1 | 6.33 |
| CHEMBL303654 | — | — | 1 | 6.24 |
| CHEMBL423123 | — | — | 1 | 5.82 |
| CHEMBL69713 | — | — | 1 | 5.17 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL34259 | METHOTREXATE | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL304397 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL305177 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL305253 | — | IC50 | = | 470.0 | nM | 6.33 |
| CHEMBL303654 | — | IC50 | = | 580.0 | nM | 6.24 |
| CHEMBL423123 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL69713 | — | IC50 | = | 6800.0 | nM | 5.17 |