Assay Detail
Binding
CHEMBL700845
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity against histamine receptor was measured using radioligand ([3H]-pyrilamine) binding assay
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Synthesis and biological evaluation of 1-(1,2-benzisothiazol-3-yl)- and (1,2-benzisoxazol-3-yl)piperazine derivatives as potential antipsychotic agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 7.30 | 7.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL42 | CLOZAPINE | 4.0 | 1 | 7.75 |
| CHEMBL1204189 | TIOSPIRONE HYDROCHLORIDE | -1.0 | 1 | 6.85 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL42 | CLOZAPINE | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL1204189 | TIOSPIRONE HYDROCHLORIDE | IC50 | = | 142.0 | nM | 6.85 |