Assay Detail
Functional
CHEMBL700895
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Effective concentration required to arrest propidium iodide stained K562 cells in G2/M phase
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | K562 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Novel benzylidene-9(10H)-anthracenones as highly active antimicrotubule agents. Synthesis, antiproliferative activity, and inhibition of tubulin polymerization.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 6.92 | 7.27 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 7.27 |
| CHEMBL9514 | NOCODAZOLE | 2.0 | 1 | 7.09 |
| CHEMBL116173 | — | — | 1 | 6.69 |
| CHEMBL112192 | — | — | 1 | 6.63 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL428647 | PACLITAXEL | EC50 | = | 54.0 | nM | 7.27 |
| CHEMBL9514 | NOCODAZOLE | EC50 | = | 82.0 | nM | 7.09 |
| CHEMBL116173 | — | EC50 | = | 206.0 | nM | 6.69 |
| CHEMBL112192 | — | EC50 | = | 234.0 | nM | 6.63 |