Assay Detail
Functional
CHEMBL700920
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro cytotoxicity against KATO-III human tumor cell line.
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | KATO III |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Synthesis and in vitro cytotoxicity of (RS)-20-desethyl-20-substituted camptothecin analogues
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 4.98 | 6.50 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL301311 | — | — | 1 | 6.50 |
| CHEMBL354150 | — | — | 1 | 6.01 |
| CHEMBL65 | CAMPTOTHECIN | -1.0 | 1 | 5.93 |
| CHEMBL352630 | — | — | 1 | 5.52 |
| CHEMBL166173 | — | — | 1 | 5.27 |
| CHEMBL354031 | — | — | 1 | 5.03 |
| CHEMBL432949 | — | — | 1 | 5.01 |
| CHEMBL355556 | — | — | 1 | 4.94 |
| CHEMBL167656 | — | — | 1 | 4.88 |
| CHEMBL169169 | — | — | 1 | 4.71 |
| CHEMBL355355 | — | — | 1 | 4.63 |
| CHEMBL355004 | — | — | 1 | 4.39 |
| CHEMBL168888 | — | — | 1 | 4.33 |
| CHEMBL166487 | — | — | 1 | 4.28 |
| CHEMBL167864 | — | — | 1 | 4.14 |
| CHEMBL353585 | — | — | 1 | 4.08 |
| CHEMBL352383 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL301311 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL354150 | — | IC50 | = | 980.0 | nM | 6.01 |
| CHEMBL65 | CAMPTOTHECIN | IC50 | = | 1170.0 | nM | 5.93 |
| CHEMBL352630 | — | IC50 | = | 3050.0 | nM | 5.52 |
| CHEMBL166173 | — | IC50 | = | 5380.0 | nM | 5.27 |
| CHEMBL354031 | — | IC50 | = | 9430.0 | nM | 5.03 |
| CHEMBL432949 | — | IC50 | = | 9720.0 | nM | 5.01 |
| CHEMBL355556 | — | IC50 | = | 11530.0 | nM | 4.94 |
| CHEMBL167656 | — | IC50 | = | 13060.0 | nM | 4.88 |
| CHEMBL169169 | — | IC50 | = | 19270.0 | nM | 4.71 |
| CHEMBL355355 | — | IC50 | = | 23250.0 | nM | 4.63 |
| CHEMBL355004 | — | IC50 | = | 40740.0 | nM | 4.39 |
| CHEMBL168888 | — | IC50 | = | 46460.0 | nM | 4.33 |
| CHEMBL166487 | — | IC50 | = | 52990.0 | nM | 4.28 |
| CHEMBL167864 | — | IC50 | = | 72290.0 | nM | 4.14 |
| CHEMBL353585 | — | IC50 | = | 83500.0 | nM | 4.08 |
| CHEMBL352383 | — | IC50 | > | 100000.0 | nM | - |