Assay Detail
Functional
CHEMBL700927
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro cytotoxicity against human tumor cell line KATO-III
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | KATO III |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Synthesis and in vitro cytotoxicity of hexacyclic camptothecin analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 6.07 | 6.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL108508 | — | — | 1 | 6.96 |
| CHEMBL322998 | — | — | 1 | 6.96 |
| CHEMBL111658 | — | — | 1 | 6.72 |
| CHEMBL109181 | — | — | 1 | 6.44 |
| CHEMBL441645 | — | — | 1 | 5.98 |
| CHEMBL109103 | — | — | 1 | 5.86 |
| CHEMBL107773 | — | — | 1 | 5.86 |
| CHEMBL321011 | — | — | 1 | 5.68 |
| CHEMBL109521 | — | — | 1 | 5.62 |
| CHEMBL109029 | — | — | 1 | 5.54 |
| CHEMBL109188 | — | — | 1 | 5.13 |
| CHEMBL322309 | — | — | 1 | - |
| CHEMBL108027 | — | — | 1 | - |
| CHEMBL65 | CAMPTOTHECIN | -1.0 | 1 | - |
| CHEMBL432606 | — | — | 1 | - |
| CHEMBL419007 | — | — | 1 | - |
| CHEMBL420670 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL108508 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL322998 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL111658 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL109181 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL441645 | — | IC50 | = | 1050.0 | nM | 5.98 |
| CHEMBL109103 | — | IC50 | = | 1380.0 | nM | 5.86 |
| CHEMBL107773 | — | IC50 | = | 1380.0 | nM | 5.86 |
| CHEMBL321011 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL109521 | — | IC50 | = | 2380.0 | nM | 5.62 |
| CHEMBL109029 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL109188 | — | IC50 | = | 7400.0 | nM | 5.13 |
| CHEMBL322309 | — | IC50 | = | 1600000.0 | nM | - |
| CHEMBL108027 | — | IC50 | = | 2900000.0 | nM | - |
| CHEMBL65 | CAMPTOTHECIN | IC50 | = | 46000000.0 | nM | - |
| CHEMBL432606 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL419007 | — | IC50 | = | 290000000.0 | nM | - |
| CHEMBL420670 | — | IC50 | = | 45000000.0 | nM | - |