Assay Detail
Functional
CHEMBL700928
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Maximum activation of human KATP (SUR1/Kir6.2) channel expressed in Xenopus oocytes
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Oocyte |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Publication
3-trifluoromethyl-4-nitro-5-arylpyrazoles are novel K(ATP) channel agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 8 | 5.85 | 7.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL354554 | — | — | 1 | 7.16 |
| CHEMBL353185 | — | — | 1 | 6.27 |
| CHEMBL422377 | — | — | 1 | 6.16 |
| CHEMBL169038 | — | — | 1 | 5.94 |
| CHEMBL181 | DIAZOXIDE | 4.0 | 1 | 5.06 |
| CHEMBL167508 | — | — | 1 | 4.52 |
| CHEMBL168681 | — | — | 1 | - |
| CHEMBL354344 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL354554 | — | EC50 | = | 70.0 | nM | 7.16 |
| CHEMBL353185 | — | EC50 | = | 540.0 | nM | 6.27 |
| CHEMBL422377 | — | EC50 | = | 700.0 | nM | 6.16 |
| CHEMBL169038 | — | EC50 | = | 1150.0 | nM | 5.94 |
| CHEMBL181 | DIAZOXIDE | EC50 | = | 8800.0 | nM | 5.06 |
| CHEMBL167508 | — | EC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL168681 | — | EC50 | > | 30000.0 | nM | - |
| CHEMBL354344 | — | EC50 | > | 30000.0 | nM | - |