Assay Detail
Binding
CHEMBL700952
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonistic activity at L-type calcium channel by displacement of [3H]diltiazem and enhanced [3H]nitrendipine binding
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
Voltage-gated L-type calcium channel (CHEMBL2095229) ↗| Type | PROTEIN FAMILY |
| Organism | Homo sapiens |
Publication
Acyclic NK-1 antagonists: 2-benzhydryl-2-aminoethyl ethers
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.92 | 6.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL16192 | CP-96345 | — | 1 | 6.62 |
| CHEMBL56427 | — | — | 1 | 6.01 |
| CHEMBL56038 | — | — | 1 | 5.78 |
| CHEMBL53901 | — | — | 1 | 5.26 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL16192 | CP-96345 | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL56427 | — | IC50 | = | 980.0 | nM | 6.01 |
| CHEMBL56038 | — | IC50 | = | 1670.0 | nM | 5.78 |
| CHEMBL53901 | — | IC50 | = | 5500.0 | nM | 5.26 |