Assay Detail
Functional
CHEMBL701009
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Evaluated in vitro for ability to inhibit the L cell lines.
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | L929 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis and biological activity of an acyclic analogue of 5,6,7,8-tetrahydrofolic acid, N-[4-[[3-(2,4-diamino-1,6-dihydro-6-oxo-5- pyrimidinyl)propyl]amino]-benzoyl]-L-glutamic acid.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 7.50 | 8.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL376180 | AMINOPTERIN | 2.0 | 1 | 8.64 |
| CHEMBL152172 | — | — | 1 | 7.75 |
| CHEMBL13659 | — | — | 1 | 7.06 |
| CHEMBL153550 | — | — | 1 | 6.55 |
| CHEMBL153544 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL376180 | AMINOPTERIN | IC50 | = | 2.3 | nM | 8.64 |
| CHEMBL152172 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL13659 | — | IC50 | = | 88.0 | nM | 7.06 |
| CHEMBL153550 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL153544 | — | IC50 | > | 100000.0 | nM | - |