Assay Detail
Functional
CHEMBL701038
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Evaluated for the uptake of Methotrexate in L1210 leukemia cells
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | L1210 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Chemistry and antitumor evaluation of selected classical 2,4-diaminoquinazoline analogues of folic acid.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.21 | 6.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL34259 | METHOTREXATE | 4.0 | 1 | 6.00 |
| CHEMBL423123 | — | — | 1 | 5.80 |
| CHEMBL305177 | — | — | 1 | 5.68 |
| CHEMBL304397 | — | — | 1 | 5.54 |
| CHEMBL305253 | — | — | 1 | 5.32 |
| CHEMBL69713 | — | — | 1 | 4.13 |
| CHEMBL303654 | — | — | 1 | 4.02 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL34259 | METHOTREXATE | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL423123 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL305177 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL304397 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL305253 | — | IC50 | = | 4800.0 | nM | 5.32 |
| CHEMBL69713 | — | IC50 | = | 74000.0 | nM | 4.13 |
| CHEMBL303654 | — | IC50 | = | 95000.0 | nM | 4.02 |