Assay Detail
Functional
CHEMBL701040
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Growth inhibition of murine tumor L1210 cell line
38
Total Activities
38
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | L1210 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Design and synthesis of potent non-polyglutamatable quinazoline antifolate thymidylate synthase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 38 | 6.50 | 8.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL225071 | RALTITREXED | 4.0 | 1 | 8.05 |
| CHEMBL126648 | PLEVITREXED | 2.0 | 1 | 7.62 |
| CHEMBL127954 | — | — | 1 | 7.30 |
| CHEMBL337914 | — | — | 1 | 7.22 |
| CHEMBL420155 | — | — | 1 | 7.16 |
| CHEMBL128033 | — | — | 1 | 7.10 |
| CHEMBL439975 | — | — | 1 | 7.00 |
| CHEMBL338598 | — | — | 1 | 6.96 |
| CHEMBL434209 | — | — | 1 | 6.89 |
| CHEMBL125856 | — | — | 1 | 6.85 |
| CHEMBL123614 | — | — | 1 | 6.82 |
| CHEMBL105346 | — | — | 1 | 6.82 |
| CHEMBL338644 | — | — | 1 | 6.80 |
| CHEMBL126325 | — | — | 1 | 6.75 |
| CHEMBL340888 | — | — | 1 | 6.72 |
| CHEMBL127541 | — | — | 1 | 6.72 |
| CHEMBL127142 | — | — | 1 | 6.68 |
| CHEMBL340842 | — | — | 1 | 6.66 |
| CHEMBL341334 | — | — | 1 | 6.64 |
| CHEMBL341323 | — | — | 1 | 6.60 |
| CHEMBL126555 | — | — | 1 | 6.55 |
| CHEMBL127745 | — | — | 1 | 6.54 |
| CHEMBL126541 | — | — | 1 | 6.52 |
| CHEMBL340814 | — | — | 1 | 6.50 |
| CHEMBL127598 | — | — | 1 | 6.50 |
| CHEMBL126697 | — | — | 1 | 6.33 |
| CHEMBL127583 | — | — | 1 | 6.24 |
| CHEMBL126242 | — | — | 1 | 6.16 |
| CHEMBL338429 | — | — | 1 | 6.14 |
| CHEMBL126914 | — | — | 1 | 6.12 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL225071 | RALTITREXED | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL126648 | PLEVITREXED | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL127954 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL337914 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL420155 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL128033 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL439975 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL338598 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL434209 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL125856 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL105346 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL123614 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL338644 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL126325 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL127541 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL340888 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL127142 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL340842 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL341334 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL341323 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL126555 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL127745 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL126541 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL340814 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL127598 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL126697 | — | IC50 | = | 470.0 | nM | 6.33 |
| CHEMBL127583 | — | IC50 | = | 580.0 | nM | 6.24 |
| CHEMBL126242 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL338429 | — | IC50 | = | 730.0 | nM | 6.14 |
| CHEMBL126914 | — | IC50 | = | 750.0 | nM | 6.12 |
| CHEMBL125971 | — | IC50 | = | 960.0 | nM | 6.02 |
| CHEMBL339022 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL441086 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL340635 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL127175 | — | IC50 | = | 5400.0 | nM | 5.27 |
| CHEMBL389051 | — | IC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL341262 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL127333 | — | IC50 | = | 6300.0 | nM | 5.20 |