Assay Detail
Functional
CHEMBL701041
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Inhibition of L1210 cell growth
33
Total Activities
33
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | L1210 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Quinazoline antifolate thymidylate synthase inhibitors: replacement of glutamic acid in the C2-methyl series.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 33 | 5.52 | 7.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL414012 | — | — | 1 | 7.10 |
| CHEMBL6676 | — | — | 1 | 7.05 |
| CHEMBL268453 | — | — | 1 | 6.68 |
| CHEMBL264095 | — | — | 1 | 6.64 |
| CHEMBL266066 | — | — | 1 | 6.21 |
| CHEMBL6632 | — | — | 1 | 6.21 |
| CHEMBL268151 | — | — | 1 | 6.18 |
| CHEMBL6436 | — | — | 1 | 6.06 |
| CHEMBL267832 | — | — | 1 | 6.02 |
| CHEMBL6496 | — | — | 1 | 5.96 |
| CHEMBL269600 | — | — | 1 | 5.77 |
| CHEMBL6715 | — | — | 1 | 5.77 |
| CHEMBL6663 | — | — | 1 | 5.70 |
| CHEMBL266509 | — | — | 1 | 5.66 |
| CHEMBL6271 | — | — | 1 | 5.61 |
| CHEMBL6788 | — | — | 1 | 5.60 |
| CHEMBL6829 | — | — | 1 | 5.40 |
| CHEMBL6317 | — | — | 1 | 5.26 |
| CHEMBL6590 | — | — | 1 | 5.26 |
| CHEMBL267702 | — | — | 1 | 5.22 |
| CHEMBL6307 | — | — | 1 | 5.14 |
| CHEMBL269342 | — | — | 1 | 5.10 |
| CHEMBL265410 | — | — | 1 | 5.07 |
| CHEMBL6636 | — | — | 1 | 5.05 |
| CHEMBL415105 | — | — | 1 | 4.96 |
| CHEMBL266956 | — | — | 1 | 4.82 |
| CHEMBL266508 | — | — | 1 | 4.60 |
| CHEMBL6498 | — | — | 1 | 4.60 |
| CHEMBL415104 | — | — | 1 | 4.39 |
| CHEMBL265669 | — | — | 1 | 4.13 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL414012 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL6676 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL268453 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL264095 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL266066 | — | IC50 | = | 620.0 | nM | 6.21 |
| CHEMBL6632 | — | IC50 | = | 620.0 | nM | 6.21 |
| CHEMBL268151 | — | IC50 | = | 660.0 | nM | 6.18 |
| CHEMBL6436 | — | IC50 | = | 880.0 | nM | 6.06 |
| CHEMBL267832 | — | IC50 | = | 960.0 | nM | 6.02 |
| CHEMBL6496 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL269600 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL6715 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL6663 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL266509 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL6271 | — | IC50 | = | 2450.0 | nM | 5.61 |
| CHEMBL6788 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL6829 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL6317 | — | IC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL6590 | — | IC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL267702 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL6307 | — | IC50 | = | 7200.0 | nM | 5.14 |
| CHEMBL269342 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL265410 | — | IC50 | = | 8600.0 | nM | 5.07 |
| CHEMBL6636 | — | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL415105 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL266956 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL266508 | — | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL6498 | — | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL415104 | — | IC50 | = | 41000.0 | nM | 4.39 |
| CHEMBL265669 | — | IC50 | = | 74000.0 | nM | 4.13 |
| CHEMBL6639 | — | IC50 | = | 90000.0 | nM | 4.05 |
| CHEMBL6560 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL268629 | — | IC50 | > | 20000.0 | nM | - |