Assay Detail
Functional
CHEMBL701042
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Ability to inhibit cell growth was measured on L1210 cells(horse serum)
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | L1210 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Quinazoline antifolate thymidylate synthase inhibitors: replacement of glutamic acid in the C2-methyl series.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.25 | 5.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL6325 | — | — | 1 | 5.92 |
| CHEMBL268100 | — | — | 1 | 5.82 |
| CHEMBL266065 | — | — | 1 | 5.75 |
| CHEMBL6775 | — | — | 1 | 5.66 |
| CHEMBL6357 | — | — | 1 | 5.41 |
| CHEMBL264097 | — | — | 1 | 5.22 |
| CHEMBL268854 | — | — | 1 | 4.16 |
| CHEMBL6850 | — | — | 1 | 4.07 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL6325 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL268100 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL266065 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL6775 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL6357 | — | IC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL264097 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL268854 | — | IC50 | = | 70000.0 | nM | 4.16 |
| CHEMBL6850 | — | IC50 | = | 85000.0 | nM | 4.07 |