Assay Detail
Functional
CHEMBL701043
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Antitumor activity against murine L1210 resistant cell line by using MTT assay
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | L1210 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Amino-substituted 2-[2'-(dimethylamino)ethyl]-1,2-dihydro-3H- dibenz[de,h]isoquinoline-1,3-diones. Synthesis, antitumor activity, and quantitative structure--activity relationship.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 25 | 6.96 | 8.57 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL146101 | — | — | 1 | 8.57 |
| CHEMBL174780 | — | — | 1 | 8.17 |
| CHEMBL290677 | AZONAFIDE | — | 1 | 8.15 |
| CHEMBL145869 | — | — | 1 | 8.10 |
| CHEMBL179290 | — | — | 1 | 7.82 |
| CHEMBL173888 | — | — | 1 | 7.82 |
| CHEMBL147597 | — | — | 1 | 7.80 |
| CHEMBL148141 | — | — | 1 | 7.70 |
| CHEMBL41290 | — | — | 1 | 7.57 |
| CHEMBL58 | MITOXANTRONE | 4.0 | 1 | 7.41 |
| CHEMBL148263 | — | — | 1 | 7.30 |
| CHEMBL174108 | — | — | 1 | 7.14 |
| CHEMBL145826 | — | — | 1 | 6.77 |
| CHEMBL147556 | — | — | 1 | 6.76 |
| CHEMBL356939 | — | — | 1 | 6.70 |
| CHEMBL146104 | — | — | 1 | 6.66 |
| CHEMBL175042 | — | — | 1 | 6.31 |
| CHEMBL177707 | — | — | 1 | 6.29 |
| CHEMBL177706 | — | — | 1 | 6.25 |
| CHEMBL428676 | AMONAFIDE | 3.0 | 1 | 6.20 |
| CHEMBL148027 | — | — | 1 | 6.17 |
| CHEMBL178220 | — | — | 1 | 6.14 |
| CHEMBL178168 | — | — | 1 | 5.61 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 5.41 |
| CHEMBL146315 | — | — | 1 | 5.17 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL146101 | — | IC50 | = | 2.7 | nM | 8.57 |
| CHEMBL174780 | — | IC50 | = | 6.8 | nM | 8.17 |
| CHEMBL290677 | AZONAFIDE | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL145869 | — | IC50 | = | 7.9 | nM | 8.10 |
| CHEMBL179290 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL173888 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL147597 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL148141 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL41290 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL58 | MITOXANTRONE | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL148263 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL174108 | — | IC50 | = | 73.0 | nM | 7.14 |
| CHEMBL145826 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL147556 | — | IC50 | = | 172.0 | nM | 6.76 |
| CHEMBL356939 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL146104 | — | IC50 | = | 219.0 | nM | 6.66 |
| CHEMBL175042 | — | IC50 | = | 487.0 | nM | 6.31 |
| CHEMBL177707 | — | IC50 | = | 510.0 | nM | 6.29 |
| CHEMBL177706 | — | IC50 | = | 560.0 | nM | 6.25 |
| CHEMBL428676 | AMONAFIDE | IC50 | = | 625.0 | nM | 6.20 |
| CHEMBL148027 | — | IC50 | = | 678.0 | nM | 6.17 |
| CHEMBL178220 | — | IC50 | = | 729.0 | nM | 6.14 |
| CHEMBL178168 | — | IC50 | = | 2433.0 | nM | 5.61 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 3884.0 | nM | 5.41 |
| CHEMBL146315 | — | IC50 | = | 6775.0 | nM | 5.17 |