Assay Detail
Binding
CHEMBL701110
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Inhibition of Integrase (3'-processing) as measured in an in vitro assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Human immunodeficiency virus type 1 integrase (CHEMBL3471) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
Design and synthesis of photoactivatable aryl diketo acid-containing HIV-1 integrase inhibitors as potential affinity probes.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.46 | 6.46 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL18927 | — | — | 1 | 6.46 |
| CHEMBL19464 | — | — | 1 | - |
| CHEMBL416364 | — | — | 1 | - |
| CHEMBL19574 | — | — | 1 | - |
| CHEMBL280299 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL18927 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL19464 | — | IC50 | < | 100.0 | nM | - |
| CHEMBL416364 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL19574 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL280299 | — | IC50 | > | 100000.0 | nM | - |