Assay Detail
Binding
CHEMBL701160
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Compound was tested for its ability to inhibit the strand transfer of the integration process catalyzed by HIV integrase
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Human immunodeficiency virus type 1 integrase (CHEMBL3471) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
Design and synthesis of 8-hydroxy-[1,6]naphthyridines as novel inhibitors of HIV-1 integrase in vitro and in infected cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 7.05 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL19464 | — | — | 1 | 8.00 |
| CHEMBL32865 | — | — | 1 | 8.00 |
| CHEMBL36070 | — | — | 1 | 7.40 |
| CHEMBL142072 | — | — | 1 | 7.30 |
| CHEMBL35842 | — | — | 1 | 6.43 |
| CHEMBL288097 | — | — | 1 | 6.22 |
| CHEMBL140319 | — | — | 1 | 6.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL19464 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL32865 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL36070 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL142072 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL35842 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL288097 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL140319 | — | IC50 | = | 1000.0 | nM | 6.00 |